2-羟基咔唑的合成与表征
河南省科学院化学研究所有限公司 濮阳惠成电子材料股份有限公司
2015-04-25
2-羟基咔唑 2-甲氧基咔唑 合成 表征
以邻溴硝基苯为起始原料,依次与双(频那醇合)二硼,对溴苯甲醚经Suzuki-Miyaura反应合成了2-硝基-4'-甲氧基联苯,然后经亚磷酸三乙酯还原反应,三溴化硼催化脱甲基化合成了目标产物2-羟基咔唑,总收率68.9%.通过1 HNMR、13 C NMR表征了合成化合物结构.%2-nitro-4’-methoxy-biphenyl was synthesized with 2-bromonitrobenzene as the starting material,sequentially reacting with bis(pinacolato)diboron and 4-bromoanisole via Suzuki-Miyaura reaction.Then this compound was reduced with triethylphosphite,followed by demethylation with BBr3 to synthesize the target product 2-hydroxycarbazole with the total yield of 68.9%.Synthetic compound was characterized by 1 HNMR and 13 C NMR.
